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                                                                                                                                              首頁 > 新聞中心 > 體外模擬人胃的實驗方法
                                                                                                                                              體外模擬人胃的實驗方法
                                                                                                                                              點擊次數:1531 發布時間:2019-03-13
                                                                                                                                                    人體對食物的消化吸收是一個非常復雜的過程,食物攝入后被轉化成營養素供機體生長。在人體消化過程中,兩個主要過程幾乎同時發生:(1)食物在消化道機械轉運過程中降低顆粒尺寸的大??;(2)食物中的大分子被水解為小分子后吸收入血。食物粉碎過程主要發生在口腔和胃,而酶解以及營養素和水的吸收主要發生在小腸和大腸。目前消化系統成為了各領域(如營養學、毒理學、生理學及微生物學等)研究者研究過程中與各種問題相聯系的焦點。但不幸的是,研究這個復雜的人體消化的多級過程存在著經濟上以及技術上的困難,并且當研究過程中涉及到潛在的有毒有害物質時還會受到倫理道德上的約束。因此迫切需求一套靈活的、的并且可重復操作的體外模擬人體消化吸收等生理過程的模型。
                                                                                                                                                過去二十幾年中,各國科學家都在嘗試制作胃腸道模型,但是大多數的體外模型都是靜態的,只包含少數模擬參數,并且只針對特定器官,如荷蘭科學家A.G.0omen等2002年開發的胃腸道消化系統消化液只包含唾液、胃液、胰液及膽汁。然而,在模擬消化道復雜的生理、生化及理化特性過程中,能夠模擬出每一餐的食物或要研究的物質在消化過程中通過消化道的時間、pH、以及酶解條件等是非常重要的。因此,一些動態的多消化器官模型被研發并應用于研究,如美國科學家KongF和SinghPR于2010年開發的人胃模擬器(HGS)用于模擬食物在胃中的消化。比利時科學K.Molly,M.VandeWoestyne,W.Verstraete于1993年開發并發展至今的模擬人體腸道微生態系統(SHME)反應器。盡管模型已復雜化,但是相比較于體內條件,現有胃腸道模型依然相對簡單,比如他們不包含反饋機制,微生物的定植,免疫系統,及的激素控制等。
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