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                                                                                                                                              首頁 > 技術與支持 > 仿生消化系統可用于品營養學研究
                                                                                                                                              仿生消化系統可用于品營養學研究
                                                                                                                                              點擊次數:436 發布時間:2021-08-30
                                                                                                                                                仿生消化系統是基于人(動物)體胃腸道生理過程,在體外條件下模擬體內消化吸收情況,用于預測或評估化合物的可消化性、生物利用率、營養成分釋放動力學特性及結構變化等研究的體外模型。
                                                                                                                                                仿生消化系統具有降低成本和時間,提高實驗重復性和準確性,可人工監控、定點取樣等優點,能夠部分或*替代活體實驗,因而沒有倫理限制,也避免了活體實驗中較大的個體差異性。
                                                                                                                                                仿生消化系統可廣泛應用于食品營養學,功能性活性物質代謝研究,藥物釋放動力研究,益生菌及益生元,食品毒理學研究,動物營養及飼料研究等。
                                                                                                                                                隨著科技的進步,越來越多的新的功能性食品和藥物被投入到市場當中,在進入市場之前,必須要進行嚴格的營養價值、杜麗、藥理等方面的實驗和評價,需要評估其營養物質以及有效活性成分在胃腸道內的消化和排空過程,認識其在體內的營養輸送過程,從而改善食品和藥物的加工方法或構建新的功能性食品,有效提高營養成分的消化吸收及藥物的利用率。此外,隨著食品安全問題日益突出,這對有效、快速、便捷的檢測食品添加劑和有毒有害成分在體內的殘留技術提出了新的挑戰。
                                                                                                                                                近年來,研究者們開發了消化系統模擬裝置,用于研究食物消化過程中的物理化學變化、食物之間相互作用、腸道益生菌存活率、功能性食品的開發和應用以及藥物和有毒有害物質在胃腸道內的殘留和代謝過程。但是現有的消化系統模擬裝置無法重現食物在真實胃內的分布及消化、排空順序,而且缺乏對胃壁或腸壁蠕動收縮的有效模擬,并且無法有效的觀察其消化過程,并且造價比較昂貴。
                                                                                                                                                
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